The show is about an eternal battle between Doggy Don, a friendly, slightly dumb dog and the 3 mice that live in his house. Doggy Don is aided in his attempts to defeat the mice by his older brother Colonel, an ex-army dog who is smarter than Doggy Don, but not as smart as the 3 mice. Each story deals with some mischief that the mice create and havoc that occurs when Doggy Don and Colonel try and fight them to win back their territory.